I like the realistic a lot, but watching footage of the Wii version, I noticed something.
A lot of times in the realistic version, you only hear the dialogue of characters who aren't there over the radio. On the Wii, it actually cuts to them, like you'll SEE Venkman sitting in the stairwell drinking coffee when he's talking about how the marshmallow dogs have him pinned down, or after the Stay Puft fight, when Ray tells the guys in Ecto-1 he's the puddle they're driving through, you actually see from the perspective of inside the Ectomobile instead of yourself on the rooftop.