That actually has crossed my mind. Reboot, originally Canadian, is an awesome show, and the best way to do any sort of crossover is through the “games”. I think, make a reboot story, but the main story is in the game, which just happens to be Ghostbusters. The user could be Stay-Puft or some big ghost, and Bob, Dot, and the others reboot into GBs, with the help of the game sprites (ie: slimer) and go on some busts before chasing down the user.
As you can see, I've thought this through…
just a thought though…