I don't want Ghostbusters to be popular because it has busty bimbo in it. Angelina Jolie is god-like, but as a ghostbuster? C'mon, let's just try and picture it first! I want to go for quality movie not a cheap gimmick such as “phwaar, big mammaries!”
I always liked
Janeane Garofalo (as The Bowler in Mystery Men - cult classic)
or even Zooey Deschanel (SJP's room-mate in Failure to Launch)
I love their dead-pan humour. I could EASILY see either as a ghostbuster.